Q) Name two penicillin drugs that are beta-lactamase resistant?
A- Nafcillin,Methicillin,Oxacillin
Q)What characteristic inherit to a drug allows it to be secreted through bile route?
A- Increased Lipocity
Q)Name two Penicillins that can be used to eradicate Pseudomonas Aeruginosa?
A- Ticarcillin,Piperacillin
Q)By what mechanism and where do penicillins get secreted generally?
A- Active tubular secretion at kidneys
Q)What type of drug sensitivity results in a positive Coombs test?
A-IgM/IgG antibodies that become fixed to cells Type II
Q)By what three mechanisms can a bacteria gain resistance to Penicillins?
A-a)Formation of Penicillanases
b)Structural changes to PBP
c)Change in Porin structures
Q)Which antibiotic is classically used in the first line treatment for Syphilis?
A-Penicillin G
Q)Describe what is Jarish-Herxheimer reaction?
A-Reaction to treatment to Syphilis
Signs and symptoms being:
Fever,swelling,joint pain.
Q)What generations of Cephalosporins can cross BBB?Name one from each generation?
A-a)3rd Generation- Ceftriaxone and Cefotaxime
b)4th generation -Cefepime(resistant to beta lactamases)
Q)What generation of Cephalosporins can be used for surgical prophylaxis ?Name two
A-1st Generation
Cefazolin,Cephalexin
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