Pharmacology - Antibiotics

Q) Name two penicillin drugs that are beta-lactamase resistant?

A- Nafcillin,Methicillin,Oxacillin

Q)What characteristic inherit to a drug allows it to be secreted through bile route?

A- Increased Lipocity

Q)Name two Penicillins that can be used to eradicate Pseudomonas Aeruginosa?

A- Ticarcillin,Piperacillin

Q)By what mechanism and where do penicillins get secreted generally?

A- Active tubular secretion at kidneys

Q)What type of drug sensitivity results in a positive Coombs test?

A-IgM/IgG antibodies that become fixed to cells Type II

Q)By what three mechanisms can a bacteria gain resistance to Penicillins?

A-a)Formation of Penicillanases

b)Structural changes to PBP

c)Change in Porin structures

Q)Which antibiotic is classically used in the first line treatment for Syphilis?

A-Penicillin G

Q)Describe what is Jarish-Herxheimer reaction?

A-Reaction to treatment to Syphilis

Signs and symptoms being:

Fever,swelling,joint pain.

Q)What generations of Cephalosporins can cross BBB?Name one from each generation?

A-a)3rd Generation- Ceftriaxone and Cefotaxime

b)4th generation -Cefepime(resistant to beta lactamases)

Q)What generation of Cephalosporins can be used for surgical prophylaxis ?Name two

A-1st Generation

Cefazolin,Cephalexin

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