1) BENZODIAZAPINES : (mnenomic - COLD)
Chlorodiazepoxide
Oxyzepam
Lorazepam
Diazepam
Alprazolam
MOA - They work for GABA Receptors of the brain.They open the post synaptic receptor GABA A receptor.This leads to increased conductance of chloride ions which produce membrane hyperpolarization and this inhibits neuronal inhibition or decrease the firing rate of neurons.
2) AZAPIRONES :
Buspirone
Gepirone
Ispapirone
MOA - Not clearly known. It does not interact with benzidiazepine receptors or modify GABAnergic transmission.It achieves its anxiolytic effects solely through D2 receptor antagonistic mechanisms.
3) SEDATIVE ANTIHISTAMINIC :
Hydroxyzine
MOA - They block the action of histamine at the receptor.Competes with histamine for binding.It is a sedative,antiemetic,antimuscarinic and selective anxiolytic.
4) BETA BLOCKER :
Propranolol
MOA - It is a beta blocker,it is a sedative.It is used to calmdown people with social phobias,agarophobias.As many symptoms of anxiety,are due to sympathetic overactivity (flight or fright) and these symptoms reinforce anxiety. Propranolol helps to give these symptoms a relief.Given adjuvant to benzodiazapines.
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